The 5.0 has been rock solid reliable for many years. This engine will be no different and in fact has stronger connecting rods. Get a reliable tune and you have nothing to worry about. If your tuner pushes every bit of timing possible out because you wanted them to, then you can kiss your...
It's going to be just like a stock S550 18+ except this time the vents already suck air straight from the grill so just get some aftermarket filters and call it a day. Don't waste money on aftermarket.